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GW 841819X

GW 841819X is a potent inducer of the ApoA1 report gene, with an EC170 of 0.22 µM, and its pIC50 for Brd2/3/4 is 5.9/6.2/6.3[1].

Product Specifications

CAS Number

146135-18-4

UNSPSC

12352005

Target

Apolipoprotein; Epigenetic Reader Domain

Related Pathways

Epigenetics; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC1=NN=C2N1C3=CC=CC=C3C(C4=CC=CC=C4)=NC2NC(OCC5=CC=CC=C5)=O

Molecular Formula

C25H21N5O2

Molecular Weight

423.47

References & Citations

[1]Olivier Mirguet, et al. Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains. J Med Chem. 2013 Oct 10;56 (19) :7501-15.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ApoA1

Frequently Asked Questions

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