GW 841819X
GW 841819X is a potent inducer of the ApoA1 report gene, with an EC170 of 0.22 µM, and its pIC50 for Brd2/3/4 is 5.9/6.2/6.3[1].
Product Specifications
CAS Number
[146135-18-4]
UNSPSC
12352005
Target
Apolipoprotein; Epigenetic Reader Domain
Related Pathways
Epigenetics; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CC1=NN=C2N1C3=CC=CC=C3C(C4=CC=CC=C4)=NC2NC(OCC5=CC=CC=C5)=O
Molecular Formula
C25H21N5O2
Molecular Weight
423.47
References & Citations
[1]Olivier Mirguet, et al. Discovery of epigenetic regulator I-BET762: lead optimization to afford a clinical candidate inhibitor of the BET bromodomains. J Med Chem. 2013 Oct 10;56 (19) :7501-15.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ApoA1
Curated Selection
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