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Methyltetrazine-Ph-NHS ester

Methyltetrazine-Ph-NHS ester is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Methyltetrazine-Ph-NHS ester is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.

Product Specifications

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(ON1C(CCC1=O)=O)CC2=CC=C(C3=NN=C(C)N=N3)C=C2

Molecular Formula

C15H13N5O4

Molecular Weight

327.30

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-130283/Methyltetrazine-Ph-NHS-ester-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Alkyl/ether Linkers

CAS Number

[1644644-96-1]

Available Sizes

Curated Selection

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