Flonoltinib (sulfate)
Flonoltinib maleate is a potent and orally active dual JAK2/FLT3 inhibitor with IC50 values of 0.7 nM, 4 nM, 26 nM and 39 nM for JAK2, FLT3, JAK1 and JAK3, respectively. Flonoltinib maleate has anti-cancer activity[1].
Product Specifications
CAS Number
[2568842-57-7]
Product Name Alternative
JAK2/FLT3-IN-1 (sulfate)
UNSPSC
12352005
Target
Apoptosis; FLT3; JAK
Related Pathways
Apoptosis; Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Field of Research
Cancer
Smiles
O=S(O)(O)=O.FC1=CC(NC2=NC(C3=CN(C(C)C)N=C3)=C(C)C=N2)=CC=C1N4CCC(CC4)N(CCO)C
Molecular Formula
C25H36FN7O5S
Molecular Weight
565.66
References & Citations
[1]Yang T, et al. Discovery of Potent and Orally Effective Dual JAK2/FLT3 Inhibitors for the Treatment of AcuteMyelogenous Leukemia and Myeloproliferative Neoplasms. J Med Chem. 2019 Oct 31.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Curated Selection
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