CC-401 (hydrochloride) (Standard)
CC-401 (hydrochloride) (Standard) is the analytical standard of CC-401 (hydrochloride) . This product is intended for research and analytical applications. CC-401 hydrochloride is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM.
Product Specifications
CAS Number
[1438391-30-0]
UNSPSC
12352100
Target
JNK; Reference Standards
Related Pathways
MAPK/ERK Pathway; Others
Field of Research
Cancer
Smiles
C1(C2=CC=CC(OCCN3CCCCC3)=C2)=NNC4=C1C=C(C=C4)C5=NC=NN5.Cl
Molecular Formula
C22H25ClN6O
Molecular Weight
424.93
References & Citations
[1]Ma FY, et al. A pathogenic role for c-Jun amino-terminal kinase signaling in renal fibrosis and tubular cell apoptosis. J Am Soc Nephrol. 2007 Feb;18 (2) :472-84.|[2]Vasilevskaya IA, et al. Inhibition of JNK Sensitizes Hypoxic Colon Cancer Cells to DNA-Damaging Agents. Clin Cancer Res. 2015 Sep 15;21 (18) :4143-52.|[3]Ma FY, et al. Blockade of the c-Jun amino terminal kinase prevents crescent formation and halts established anti-GBM glomerulonephritis in the rat. Lab Invest. 2009 Apr;89 (4) :470-84.
Shipping Conditions
Room temperature
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-13022R/
Scientific Category
Reference Standards
Available Sizes
Curated Selection
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