TMPRSS6-IN-1 (TFA)
TMPRSS6-IN-1 (TFA) is a potent inhibitor of TMPRSS6 (Matriptase-2), belonging to TTSPs (transmembrane serine protease) . TMPRSS6, is a type II TTSP, the genetic reduction of which will improve symptoms of hemochromatosis and beta thalassemia in mice[1].
Product Specifications
UNSPSC
12352005
Target
Ser/Thr Protease; TMPRSS6
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Purity
99.62
Smiles
NC(NCCC[C@H](NC([C@@H](NC([C@@H](NC(CCC1=CC=CC=C1)=O)CC2=CSC=N2)=O)C(C)C)=O)C(C3=NC4=C(S3)C=CC=C4)=O)=N.OC(C(F)(F)F)=O
Molecular Formula
C35H41F3N8O6S2
Molecular Weight
790.88
References & Citations
[1]St-Georges C, et al. Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids. Eur J Med Chem. 2017 Mar 31;129:110-123.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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