Quizartinib-d8
Quizartinib-d8 (AC220-d8) is deuterium labeled Quizartinib. Quizartinib (AC220) is an orally active, highly selective and potent second-generation type II FLT3 tyrosine kinase inhibitor, with a Kd of 1.6 nM. Quizartinib inhibits wild-type FLT3 and FLT3-ITD autophosphorylation in MV4-11 cells with IC50s of 4.2 and 1.1 nM, respectively. Quizartinib can be linked to the VHL ligand via an optimized linker to form a PROTAC FLT3 degrader. Quizartinib induces apoptosis[1].
Product Specifications
CAS Number
1300734-19-3
Product Name Alternative
AC220-d8; AC708-d8
UNSPSC
12352005
Target
Apoptosis; FLT3; Isotope-Labeled Compounds; Ligands for Target Protein for PROTAC
Related Pathways
Apoptosis; Others; PROTAC; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
[2H]C1([2H])C([2H])([2H])OC([2H])([2H])C([2H])([2H])N1CCOC2=CC=C(N3C(S4)=NC(C5=CC=C(C=C5)NC(NC6=NOC(C(C)(C)C)=C6)=O)=C3)C4=C2
Molecular Formula
C29H24D8N6O4S
Molecular Weight
568.72
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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