JNJ-17166864
JNJ-17166864 is a highly selective CCR2 antagonist. JNJ-17166864 has low oral bioavailability. JNJ-17166864 can significantly reduce the area of alveolar bone loss in a mouse model of periodontitis induced by Porphyromonas gingivalis infection. JNJ-17166864 can be used in the research of inflammatory diseases such as allergic rhinitis and periodontitis[1][2].
Product Specifications
CAS Number
[874887-03-3]
UNSPSC
12352005
Target
CCR
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Field of Research
Inflammation/Immunology
Smiles
C[N+](C)(CC1=CC=C(NC(C2=CC=C(Cl)C(Cl)=C2)=O)C=C1)C3CCOCC3.[Cl-]
Molecular Formula
C21H25Cl3N2O2
Molecular Weight
443.79
References & Citations
[1]Covino DA, et al. The CCL2/CCR2 Axis in the Pathogenesis of HIV-1 Infection: A New Cellular Target for Therapy? Curr Drug Targets. 2016;17 (1) :76-110.|[2]Zhang J, et al. Chemokine (C-C motif) receptor 2 mediates mast cell migration to abdominal aortic aneurysm lesions in mice. Cardiovasc Res. 2012 Dec 1;96 (3) :543-51.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CCR2
Curated Selection
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