AZD6642

AZD6642 is a 5-lipoxygenase activating protein (FLAP) inhibitor. AZD6642 can effectively inhibit the production of LTB4. AZD6642 exhibits high oral bioavailability in rats and dogs. AZD6642 can be used in the research of inflammatory diseases[1].

Product Specifications

CAS Number

[1643809-54-4]

UNSPSC

12352005

Target

FLAP; Leukotriene Receptor

Related Pathways

GPCR/G Protein; Immunology/Inflammation

Field of Research

Inflammation/Immunology

Smiles

CC(C)(O)CNC(C1=NC=C([C@]2(C3=CC=C(C4=NC=C(N)N=C4)C=C3)CCCO2)C=C1)=O

Molecular Formula

C24H27N5O3

Molecular Weight

433.50

References & Citations

[1]Lemurell M, et al. Discovery of AZD6642, an inhibitor of 5-lipoxygenase activating protein (FLAP) for the treatment of inflammatory diseases. J Med Chem. 2015 Jan 22;58 (2) :897-911.