PRT-060318 (dihydrochloride)
PRT-060318 (PRT318) dihydrochloride is a potent, selective and orally active tyrosine kinase Syk inhibitor with an IC50 of 3 nM. PRT-060318 dihydrochloride suppresses chronic lymphocytic leukemia (CLL) B cell activation and migration, and induces apoptosis. PRT-060318 dihydrochloride prevents Heparin -induced thrombocytopenia and thrombosis in a transgenic mouse model. PRT-060318 dihydrochloride can be used for CLL and thrombus research[1][2].
Product Specifications
CAS Number
3032567-93-1
Product Name Alternative
PRT318 (dihydrochloride)
UNSPSC
12352005
Target
Apoptosis; Syk
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer; Inflammation/Immunology
Purity
98.98
Smiles
O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N.Cl.Cl
Molecular Formula
C18H26Cl2N6O
Molecular Weight
413.34
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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