IAXO-101 (iodide)

IAXO-101 iodide is a TLR4/CD14 blocker. IAXO-101 iodide can inhibit the innate immune pathway of CD14. IAXO-101 iodide is capable of improving the recording performance of intracortical microelectrodes in mice. IAXO-101 iodide can also partially alleviate fetal growth restriction, placental vascular damage, and reduce the level of the inflammatory factor TNF-α in pregnant mice infected with malaria. IAXO-101 iodide can be used in the research of gestational malaria and inflammatory diseases[1][2].

Product Specifications

CAS Number

[1202388-64-4]

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Infection; Inflammation/Immunology

Smiles

CCCCCCCCCCCCCCO[C@@H]1[C@H]([C@@H]([C@@H](C[N+](C)(C2CCCC2)C)O[C@@H]1OC)O)OCCCCCCCCCCCCCC.[I-]

Molecular Formula

C42H84INO5

Molecular Weight

810.02

References & Citations

[1]Hermann JK, et al. Inhibition of the cluster of differentiation 14 innate immunity pathway with IAXO-101 improves chronic microelectrode performance. J Neural Eng. 2018 Apr;15 (2) :025002.|[2]Barboza R, et al. TLR4-Mediated Placental Pathology and Pregnancy Outcome in Experimental Malaria. Sci Rep. 2017 Aug 17;7 (1) :8623.