KMUP-1

KMUP-1 is a xanthine derivative with vasodilator activity. KMUP-1 is a inhibitor of phosphodiesterase (PDE) and activator of soluble guanylyl cyclase (sGC) . KMUP-1 stimulates NO/sGC/cyclic GMP pathway. KMUP-1 has K+ channels opening activity. KMUP-1 ameliorates ischemia-induced cardiomyocyte apoptosis. KMUP-1 can be used for cardiovascular and anti-inflammatory study[1][2].

Product Specifications

CAS Number

[81996-46-5]

UNSPSC

12352005

Hazard Statement

H301-H315-H319-H335

Target

Apoptosis; Guanylate Cyclase; Phosphodiesterase (PDE) ; Potassium Channel

Related Pathways

Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology; Cardiovascular Disease

Purity

90.000000

Smiles

O=C(N1C)N(C)C2=C(N(CCN3CCN(C4=CC=CC=C4Cl)CC3)C=N2)C1=O

Molecular Formula

C19H23ClN6O2

Molecular Weight

402.88

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Wu BN, et al. A xanthine-based KMUP-1 with cyclic GMP enhancing and K (+) channels opening activities in rat aortic smooth muscle. Br J Pharmacol. 2001 Sep;134 (2) :265-74. |[2]Lee ML, et al. KMUP-1 Ameliorates Ischemia-Induced Cardiomyocyte Apoptosis through the NO⁻cGMP⁻MAPK Signaling Pathways. Molecules. 2019 Apr 8;24 (7) :1376.