RO4583298

RO4583298 is a potent, orally active dual antagonist of NK1 (human and gerbil) /NK3 (human, cynomolgus monkey, gerbil and guinea-pig) . RO4583298 inhibits senktide-induced potentiation of spontaneous activity of dopaminergic neurons. RO4583298 can block gerbil foot tapping response and inhibits mouse tail whips[1].

Product Specifications

CAS Number

825643-56-9

UNSPSC

12352005

Target

Neurokinin Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=C(N(C1=C(C2=CC=C(F)C=C2C)C=C(N3[C@H](CO)[C@@H](O)CC3)N=C1)C)C(C)(C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4

Molecular Formula

C30H30F7N3O3

Molecular Weight

613.57

References & Citations

[1]Malherbe, P., et al., (2011) . Characterization of RO4583298 as a novel potent, dual antagonist with in vivo activity at tachykinin NK₁ and NK₃ receptors. British journal of pharmacology, 162 (4), 929-946.