RO4583298
RO4583298 is a potent, orally active dual antagonist of NK1 (human and gerbil) /NK3 (human, cynomolgus monkey, gerbil and guinea-pig) . RO4583298 inhibits senktide-induced potentiation of spontaneous activity of dopaminergic neurons. RO4583298 can block gerbil foot tapping response and inhibits mouse tail whips[1].
Product Specifications
CAS Number
825643-56-9
UNSPSC
12352005
Target
Neurokinin Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=C(N(C1=C(C2=CC=C(F)C=C2C)C=C(N3[C@H](CO)[C@@H](O)CC3)N=C1)C)C(C)(C)C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4
Molecular Formula
C30H30F7N3O3
Molecular Weight
613.57
References & Citations
[1]Malherbe, P., et al., (2011) . Characterization of RO4583298 as a novel potent, dual antagonist with in vivo activity at tachykinin NK₁ and NK₃ receptors. British journal of pharmacology, 162 (4), 929-946.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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