MNA 279
MNA 279 (X 910279) is an orally active, immunosuppressive malononitrilamide and A 771726 derivative. MNA 279 suppresses IgM and IgG antibody production. MNA 279 prevents the development of systemic lupus erythematosus (SLE) -like disease in mice. MNA 279 prolongs skin xenograft survival in a mouse-to-rat model[1][2].
Product Specifications
CAS Number
185915-32-6
Product Name Alternative
X 910279; HMR-279; FK-779
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Drug Derivative
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Smiles
N#CC1=CC=C(NC(C(C(C2CC2)=O)C#N)=O)C=C1
Molecular Formula
C14H11N3O2
Molecular Weight
253.26
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Schorlemmer HU, et al. Prevention of the development of murine systemic lupus erythematosus (SLE) -like diseases by the malononitrilamides MNA 279 and MNA 715. Inflamm Res. 1997 Aug;46 Suppl 2:S167-8. |[2]Schorlemmer HU, et al. The new immunosuppressive malononitrilamide MNA 279 prolongs skin xenograft survival in a mouse-to-rat model. Transplant Proc. 1997 Dec;29 (8) :3497-500.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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