Metoprine (Standard)
Metoprine (Standard) is the analytical standard of Metoprine. This product is intended for research and analytical applications. Metoprine (BW 197U) is a potent histamine N-methyltransferase (HMT) inhibitor. Metoprine, a diaminopyrimidine derivative, can cross the blood-brain barrier and increase brain histamine levels by inhibiting HMT[1][2]. Metoprine is an antifolate and antitumor agent[3].
Product Specifications
CAS Number
7761-45-7
UNSPSC
12352100
Target
Antifolate; Histone Methyltransferase; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Others
Field of Research
Cancer; Neurological Disease
Smiles
CC1=C(C(N)=NC(N)=N1)C2=CC=C(C(Cl)=C2)Cl
Molecular Formula
C11H10Cl2N4
Molecular Weight
269.13
References & Citations
[1]Junichi Kitanaka, et al. Brain Histamine N-Methyltransferase As a Possible Target of Treatment for Methamphetamine Overdose. Drug Target Insights. 2016 Mar 2;10:1-7.|[2]Zhong Chen, et al. Effects of brain histamine on memory deficit induced by nucleus basalis-lesion in rats. Acta Pharmacol Sin. 2002 Jan;23 (1) :66-70.|[3]John R Horton, et al. Structural basis for inhibition of histamine N-methyltransferase by diverse drugs. J Mol Biol. 2005 Oct 21;353 (2) :334-344.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
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