(-) -Deacetylsclerotiorin

(-) -Deacetylsclerotiorin (Compound 30) is the enantiomer of Deacetylsclerotiorin (HY-126167) . Deacetylsclerotiorin is the metabolite of chloramphenicol isolated from the fungus Bartalinia robillardoides strain LF550. Deacetylsclerotiorin has significant inhibitory effects on Candida albicans (IC50=24 μM), Trichophyton rubrum (IC50=2.83 μM) and Septoria tritici (IC50=7.45 μM) . In addition, Deacetylsclerotiorin also exhibits inhibitory effects on the enzyme phosphodiesterase 4 (PDE4) (IC50=2.8 μM) [1].

Product Specifications

CAS Number

[61248-35-9]

UNSPSC

12352005

Target

Fungal; Phosphodiesterase (PDE)

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Field of Research

Infection

Smiles

ClC1=C2C(C([C@](O)(C1=O)C)=O)=COC(/C=C/C(C)=C/[C@@H](C)CC)=C2

Molecular Formula

C19H21ClO4

Molecular Weight

348.82

References & Citations

[1]Germain AR, et al., Synthesis of the azaphilones (+) -sclerotiorin and (+) -8-O-methylsclerotiorinamine utilizing (+) -sparteine surrogates in copper-mediated oxidative dearomatization. J Org Chem. 2011 Apr 15;76 (8) :2577-84.