Pulrodemstat (hydrochloride)

Pulrodemstat (CC-90011) hydrochloride is a potent, selective, reversible and orally active inhibitor of lysine specific demethylase-1 (LSD1) with an IC50 value of 0.25 nM. Pulrodemstat hydrochloride is less enzymatic inhibition against LSD2, MOA-A, and MAO-B. Pulrodemstat hydrochloride induces acute myeloid leukemia (AML) and small cell lung cancer (SCLC) cells differentiation and has potent anticancer activity[1].

Product Specifications

CAS Number

[1821307-11-2]

Product Name Alternative

CC-90011 (hydrochloride) ; LSD1-IN-7 (hydrochloride)

UNSPSC

12352005

Target

Histone Demethylase

Related Pathways

Epigenetics

Field of Research

Cancer

Smiles

N#CC1=CC=C(C(N=C(N2CCC(N)CC2)N3C)=C(C4=CC=C(OC)C(F)=C4)C3=O)C=C1F.Cl

Molecular Formula

C24H24ClF2N5O2

Molecular Weight

487.93

References & Citations

[1]Toufike Kanouni, et al. Discovery of CC-90011: A Potent and Selective Reversible Inhibitor of Lysine Specific Demethylase 1 (LSD1) . J Med Chem. 2020 Dec 10;63 (23) :14522-14529.