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XS018661

XS018661 is a dual inhibitor of the YEATS domains of ENL and its paralog AF9 with IC50 values of 1.6 and 3 μM as well as Kd values of 754 nM and 523 nM, respectively[1].

Product Specifications

CAS Number

878415-59-9

UNSPSC

12352005

Target

Epigenetic Reader Domain

Related Pathways

Epigenetics

Field of Research

Cancer

Smiles

O=C(OC)C1=CC=C(C=C1)C(=O)NC=2C=CC=3N=C(NC3C2)CN4CCCCC4

Molecular Formula

C22H24N4O3

Molecular Weight

392.46

References & Citations

[1]Christott T, et al., Discovery of a Selective Inhibitor for the YEATS Domains of ENL/AF9. SLAS Discov. 2019 Feb;24 (2) :133-141.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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