Clomethiazole (Standard)

Clomethiazole (Standard) is the analytical standard of Clomethiazole. This product is intended for research and analytical applications. Chlormethiazole is an potent and orally active GABAA agonist[1]. Chlormethiazole inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes. Chlormethiazole is an anticonvulsant agent and has the potential for treating convulsive status epilepticus[2].

Product Specifications

CAS Number

[533-45-9]

UNSPSC

12352100

Target

Cytochrome P450; GABA Receptor; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

CC1=C(CCCl)SC=N1

Molecular Formula

C6H8ClNS

Molecular Weight

161.65

References & Citations

[1]Nelson RM, et al.Electrophysiological actions of gamma-aminobutyric acid and clomethiazole on recombinant GABA (A) receptors.Eur J Pharmacol. 2002 Oct 11;452 (3) :255-62.|[2]Stresser DM, et al. Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole.Drug Metab Dispos. 2016 Aug;44 (8) :1424-30