Clomethiazole (Standard)
Clomethiazole (Standard) is the analytical standard of Clomethiazole. This product is intended for research and analytical applications. Chlormethiazole is an potent and orally active GABAA agonist[1]. Chlormethiazole inhibits cytochrome P450 isoforms: CYP2A6 and CYP2E1 in human liver microsomes. Chlormethiazole is an anticonvulsant agent and has the potential for treating convulsive status epilepticus[2].
Product Specifications
CAS Number
533-45-9
UNSPSC
12352100
Target
Cytochrome P450; GABA Receptor; Reference Standards
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
CC1=C(CCCl)SC=N1
Molecular Formula
C6H8ClNS
Molecular Weight
161.65
References & Citations
[1]Nelson RM, et al.Electrophysiological actions of gamma-aminobutyric acid and clomethiazole on recombinant GABA (A) receptors.Eur J Pharmacol. 2002 Oct 11;452 (3) :255-62.|[2]Stresser DM, et al. Selective Time- and NADPH-Dependent Inhibition of Human CYP2E1 by Clomethiazole.Drug Metab Dispos. 2016 Aug;44 (8) :1424-30
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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