N-Desmethyltamoxifen (hydrochloride) (Standard)

N-Desmethyltamoxifen (hydrochloride) (Standard) is the analytical standard of N-Desmethyltamoxifen (hydrochloride) . This product is intended for research and analytical applications. N-Desmethyltamoxifen hydrochloride is the major metabolite of tamoxifen in humans. N-Desmethyltamoxifen, a poor antiestrogen, is a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen. N-Desmethyltamoxifen hydrochloride is also a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation[1][2][3].

Product Specifications

CAS Number

[15917-65-4]

UNSPSC

12352005

Hazard Statement

H350-H360-H400-H410

Target

Drug Metabolite; Endogenous Metabolite; Estrogen Receptor/ERR; PKC; Reference Standards

Related Pathways

Epigenetics; Metabolic Enzyme/Protease; Others; TGF-beta/Smad; Vitamin D Related/Nuclear Receptor

Field of Research

Cancer

Smiles

CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCNC)C=C2)\C3=CC=CC=C3.[H]Cl

Molecular Formula

C25H28ClNO

Molecular Weight

393.95

Precautions

P273-P280-P391-P405-P501

References & Citations

[1]Vertosick FT Jr, et al. A comparison of the relative chemosensitivity of human gliomas to tamoxifen and n-desmethyltamoxifen in vitro. J Neurooncol. 1994;19 (2) :97-103.|[2]Morad SA, et al. Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics. Biochim Biophys Acta. 2015 Jul;1851 (7) :919-28.|[3]Reddel RR, et al. N-desmethyltamoxifen inhibits growth of MCF 7 human mammary carcinoma cells in vitro. Eur J Cancer Clin Oncol. 1983 Aug;19 (8) :1179-81.