(-) -MDO-NPA
(-) -MDO-NPA is an N-propylnorapomorphine analog and a D1R/D2R dual-target ligand. (-) -MDO-NPA has EC50 values of 1949 nM (D1R) and 520 nM (D2R) for β-arrestin. (-) -MDO-NPA has EC50 values of 717.5 nM (D1R) and 7.7 nM (D2R) for cAMP. (-) -MDO-NPA can be used in the research of dopamine-related diseases such as Parkinson’s disease[1].
Product Specifications
CAS Number
[81264-57-5]
UNSPSC
12352005
Target
Dopamine Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CCCN1[C@@]2([H])C3=C(CC1)C=CC=C3C4=C(C2)C=CC5=C4OCO5
Molecular Formula
C20H21NO2
Molecular Weight
307.39
References & Citations
[1]Park H, et al. Structure-Functional-Selectivity Relationship Studies of Novel Apomorphine Analogs to Develop D1R/D2R Biased Ligands. ACS Med Chem Lett. 2020 Jan 6;11 (3) :385-392.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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