Macozinone (Standard)
Macozinone (Standard) is the analytical standard of Macozinone. This product is intended for research and analytical applications. Macozinone (PBTZ169) is a bactericidal benzothiazinone and a potent DprE1 (decaprenylphosphoryl-β-d-ribose 2′-oxidase) inhibitor. Macozinone inhibits the essential flavoprotein DprE1 by forming a covalent bond with the active-site Cys387 residue. Macozinone has antituberculosis effect[1][2].
Product Specifications
CAS Number
[1377239-83-2]
Product Name Alternative
PBTZ169 (Standard)
UNSPSC
12352005
Target
Antibiotic; Bacterial; Reference Standards
Related Pathways
Anti-infection; Others
Field of Research
Infection
Smiles
O=C1C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2SC(N3CCN(CC4CCCCC4)CC3)=N1
Molecular Formula
C20H23F3N4O3S
Molecular Weight
456.48
References & Citations
[1][3] Makarov V et al. Towards a new combination therapy for tuberculosis with next generation benzothiazinones.
 EMBO Mol Med. 2014 Mar;6 (3) :372-83.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Available Sizes
Curated Selection
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