GGFG-Exatecan (TFA)
GGFG-Exatecan TFA is a synthetic intermediate for drug-linker conjugates used in antibody-drug conjugates (ADCs) . GGFG-Exatecan TFA consists of a glycyl-glycyl-phenylalanyl-glycine (GGFG) tetrapeptide linker and a DNA topoisomerase I inhibitor Exatecan (HY-13631) . GGFG-Exatecan TFA can be used for the study of cancer[1].
Product Specifications
CAS Number
[223537-11-9]
UNSPSC
12352005
Target
Drug Intermediate
Related Pathways
Others
Field of Research
Cancer
Purity
96.97
Smiles
NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C41H41F4N7O10
Molecular Weight
867.80
References & Citations
[1]Nakada T, et al. Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads. Bioorg Med Chem Lett. 2016 Mar 15;26 (6) :1542-1545.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Curated Selection
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