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GGFG-Exatecan

GGFG-Exatecan is a synthetic intermediate for drug-linker conjugates used in antibody-drug conjugates (ADCs). GGFG-Exatecan consists of a glycyl-glycyl-phenylalanyl-glycine (GGFG) tetrapeptide linker and a DNA topoisomerase I inhibitor Exatecan. GGFG-Exatecan can be used for the study of cancer[1].

Product Specifications

CAS Number

223537-10-8

UNSPSC

12352005

Target

Drug Intermediate

Related Pathways

Others

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

NCC(NCC(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@@H]2C3=C4C(C(N5C4)=CC([C@](O)(C(OC6)=O)CC)=C6C5=O)=NC7=CC(F)=C(C)C(CC2)=C73)=O)=O)=O)=O

Molecular Formula

C39H40FN7O8

Molecular Weight

753.78

References & Citations

[1]Nakada T, et al. Novel antibody drug conjugates containing exatecan derivative-based cytotoxic payloads. Bioorg Med Chem Lett. 2016 Mar 15;26 (6) :1542-1545.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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