(S) -FTY-720 Vinylphosphonate
(S) -FTY-720 Vinylphosphonate is a chiral phosphonate analogue of Fingolimod. (S) -FTY-720 Vinylphosphonate can activate the S1P1 receptor with an EC50 value of 75 nM. (S) -FTY-720 Vinylphosphonate can significantly inhibit Camptothecin (HY-16560) -induced apoptosis in IEC-6 cells. (S) -FTY-720 Vinylphosphonate is applicable for the research of autoimmune diseases[1].
Product Specifications
CAS Number
1142015-13-1
UNSPSC
12352005
Target
Apoptosis; LPL Receptor
Related Pathways
Apoptosis; GPCR/G Protein
Field of Research
Inflammation/Immunology
Smiles
O=P(O)(O)/C=C/[C@@](CO)(N)CCC1=CC=C(C=C1)CCCCCCCC
Molecular Formula
C20H34NO4P
Molecular Weight
383.46
References & Citations
[1]Lu X, Sun C, et al. Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720. J Org Chem. 2009 Apr 17;74 (8) :3192-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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