(rel) -Nutlin carboxylic acid

(rel) -Nutlin carboxylic acid is the Nutlin 3-based MDM2 ligand. (rel) -Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTAC[1].

Product Specifications

CAS Number

[2760669-71-2]

UNSPSC

12352005

Target

Ligands for E3 Ligase

Related Pathways

PROTAC

Field of Research

Cancer

Smiles

O=C(N1CC(N(CC1)CC(O)=O)=O)N2[C@H](C3=CC=C(C=C3)Cl)[C@H](C4=CC=C(C=C4)Cl)N=C2C5=C(C=C(C=C5)OC)OC(C)C

Molecular Formula

C32H32Cl2N4O6

Molecular Weight

639.53

References & Citations

[1]Li G, et al. A PARP1 PROTAC as a novel strategy against PARP inhibitor resistance via promotion of ferroptosis in p53-positive breast cancer. Biochem Pharmacol. 2022 Dec;206:115329.