(rel) -Nutlin carboxylic acid
(rel) -Nutlin carboxylic acid is the Nutlin 3-based MDM2 ligand. (rel) -Nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTAC[1].
Product Specifications
CAS Number
2760669-71-2
UNSPSC
12352005
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C(N1CC(N(CC1)CC(O)=O)=O)N2[C@H](C3=CC=C(C=C3)Cl)[C@H](C4=CC=C(C=C4)Cl)N=C2C5=C(C=C(C=C5)OC)OC(C)C
Molecular Formula
C32H32Cl2N4O6
Molecular Weight
639.53
References & Citations
[1]Li G, et al. A PARP1 PROTAC as a novel strategy against PARP inhibitor resistance via promotion of ferroptosis in p53-positive breast cancer. Biochem Pharmacol. 2022 Dec;206:115329.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MDM2
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