Ifenprodil (tartrate) (Standard)

Ifenprodil (tartrate) (Standard) is the analytical standard of Ifenprodil (tartrate) . This product is intended for research and analytical applications. Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM) [1]. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator[2].

Product Specifications

CAS Number

[23210-58-4]

Product Name Alternative

NP-120 (tartrate) (Standard) ; RC-61-91 (tartrate) (Standard)

UNSPSC

12352005

Target

IGluR; Potassium Channel; Reference Standards

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

OC(C1=CC=C(O)C=C1)C(C)N(CC2)CCC2CC3=CC=CC=C3.O=C(O)[C@H](O)[C@@H](O)C(O)=O.[1/2]

Molecular Formula

C21H27NO2.1/2C4H6O6

Molecular Weight

400.49

References & Citations

[1]Williams K, et al. Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol Pharmacol. 1993 Oct;44 (4) :851-9.|[2]Kobayashi T, et al. Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil. Neuropsychopharmacology. 2006 Mar;31 (3) :516-24.