CL097 (Standard)

CL097 (Standard) is the analytical standard of CL097. This product is intended for research and analytical applications. CL097, a potent TLR7 and TLR8 agonist, induces pro-inflammatory cytokines in macrophages[1]. CL097 induces NADPH oxidase priming, resulting in an increase of the fMLF-stimulated ROS production[2].

Product Specifications

CAS Number

[1026249-18-2]

UNSPSC

12352100

Target

Reactive Oxygen Species (ROS) ; Reference Standards; Toll-like Receptor (TLR)

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Inflammation/Immunology

Smiles

NC1=NC2=CC=CC=C2C3=C1NC(COCC)=N3

Molecular Formula

C13H14N4O

Molecular Weight

242.28

References & Citations

[1]Cindy Patinote, et al. Agonist and antagonist ligands of toll-like receptors 7 and 8: Ingenious tools for therapeutic purposes. Eur J Med Chem. 2020 May 1;193:112238.|[2]Karama Makni-Maalej, et al. The TLR7/8 agonist CL097 primes N-formyl-methionyl-leucyl-phenylalanine-stimulated NADPH oxidase activation in human neutrophils: critical role of p47phox phosphorylation and the proline isomerase Pin1. J Immunol. 2012 Nov 1;189 (9) :4657-65.|[3]A S Lee, et al. Toll-like receptor 7 stimulation promotes autoimmune diabetes in the NOD mouse. Diabetologia. 2011 Jun;54 (6) :1407-16.