D-Glucaric acid (tetrahydrate)

D-Glucaric acid tetrahydrate (Calcium D-glucarate tetrahydrate) is an orally active end product of the mammalian D-glucuronidation pathway. D-Glucaric acid tetrahydrate is found in a variety of fruits and vegetables. D-Glucaric acid tetrahydrate induces cell Apoptosis. D-Glucaric acid tetrahydrate reduces the expression of hippocampal myelin-related genes (Mbp, Plp1) . D-Glucaric acid tetrahydrate has cholesterol-lowering and anti-tumor activities. D-Glucaric acid tetrahydrate can be used in the research of neurological diseases[1][2][3].

Product Specifications

CAS Number

[5793-89-5]

Product Name Alternative

Calcium D-glucarate (tetrahydrate)

UNSPSC

12352211

Hazard Statement

H315, H319, H335

Target

Apoptosis; Endogenous Metabolite

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Purity

99.87

Solubility

H2O : 1.92 mg/mL (ultrasonic; adjust pH to 2 with HCl)

Smiles

[O-]C([C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O)=O.[H]O[H].[H]O[H].[H]O[H].[H]O[H].[Ca+2]

Molecular Formula

C6H16CaO12

Molecular Weight

320.26

Precautions

H315, H319, H335

References & Citations

[1]Walaszek Z, et al. D-glucaric acid content of various fruits and vegetables and cholesterol-lowering effects of dietary D-glucarate in the rat. Nutrition Research, 1996, 16 (4) : 673-681.|[2]Zółtaszek R, et al. Biologiczna rola kwasu D-glukarowego i jego pochodnych; potencjalne zastosowanie w medycynie [The biological role of D-glucaric acid and its derivatives: potential use in medicine]. Postepy Hig Med Dosw (Online) . 2008 Sep 5;62:451-62. |[3]Kambe J, et al. Hydrogen peroxide in breast milk is crucial for gut microbiota formation and myelin development in neonatal mice. Gut Microbes. 2024 Jan-Dec;16 (1) :2359729.