Abemaciclib metabolite M2 (Standard)

Abemaciclib metabolite M2 (Standard) is the analytical standard of Abemaciclib metabolite M2. This product is intended for research and analytical applications. Abemaciclib metabolite M2 (LSN2839567) is a metabolite of Abemaciclib, acts as a potent CDK4 and CDK6 inhibitor, with IC50s of 1.2 and 1.3 nM, respectively. Anti-cancer activity[1][2].

Product Specifications

CAS Number

[1231930-57-6]

Product Name Alternative

LSN2839567 (Standard)

UNSPSC

12352005

Target

CDK; Drug Metabolite; Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Others

Field of Research

Cancer

Smiles

CC(N1C2=CC(C3=NC(NC4=NC=C(CN5CCNCC5)C=C4)=NC=C3F)=CC(F)=C2N=C1C)C

Molecular Formula

C25H28F2N8

Molecular Weight

478.54

References & Citations

[1]Teresa Burke, et al. Abstract 2830: The major human metabolites of abemaciclib are inhibitors of CDK4 and CDK6. Cancer Research. July 2016, 76 (14) .|[2]CHMP. Assessment report Verzenios. 26 July 2018 EMA/551438/2018.