RYL-634
RYL-634 is a potent broad-spectrum antiviral agent. RYL-634 exerts its antiviral effect by inhibiting the activity of human dihydroorotate dehydrogenase (HsDHODH) and blocking the supply of pyrimidines required for viral replication. RYL-634 shows significant inhibition against many viruses, with the EC50 values against DENV, ZIKV, EV71, HCV and HIV are 7 nM, 20 nM, 4 nM, 5 nM and 13 nM respectively. RYL-634 can be used for the study of various virus infection-related diseases[1].
Product Specifications
CAS Number
2187352-99-2
UNSPSC
12352005
Target
Dengue Virus; HCV; Influenza Virus
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C1C(C)=C(C2=CC(F)=C(OC3=CC=C(N(CC)CC)C=C3)C=C2)NC4=CC=CC(F)=C41
Molecular Formula
C26H24F2N2O2
Molecular Weight
434.48
References & Citations
[1]Yang Y, et al. Discovery, Optimization, and Target Identification of Novel Potent Broad-Spectrum Antiviral Inhibitors. J Med Chem. 2019 Apr 25;62 (8) :4056-4073.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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