DHW-208

PI3K-IN-4 is a potent Pan-PI3K inhibitor. PI3K-IN-4 has high activity for three PI3K isoforms with the IC50 values of picomole. PI3K-IN-4 shows superior inhibitory activity against PI3Kα (IC50 = 0.20 nM), PI3Kβ (IC50 = 2.99 nM), PI3Kδ (IC50 = 0.48 nM) and PI3Kγ (IC50 = 0.58 nM) and has no significant activity against EGFR. PI3K-IN-4 inhibits cancer cell growth though PI3K/Akt signaling pathway, leading to the inhibition of colony formation and the induction of apoptosis. PI3K-IN-4 can be used for lung, colon and breast cancer research[1].

Product Specifications

CAS Number

[2269470-35-9]

UNSPSC

12352005

Target

Akt; Apoptosis; PI3K

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Field of Research

Cancer

Smiles

COC(N=C1)=C(NS(=O)(C2=CC=C(F)C=C2F)=O)C=C1C3=CC=C(N=CN=C4NC5=CN(CCO)N=C5)C4=C3

Molecular Formula

C25H21F2N7O4S

Molecular Weight

553.54

References & Citations

[1]Ding HW, et al. Design, synthesis, and biological evaluation of some novel 4-aminoquinazolines as Pan-PI3K inhibitors. Bioorg Med Chem. 2019 Jul 1;27 (13) :2729-2740.