Tetrathiomolybdate
Tetrathiomolybdate, an orally active anti-copper agent, reduces copper levels in the body. Tetrathiomolybdate has a protective effect on collagen-induced arthritis in mice. Tetrathiomolybdate also reduces blood sugar, but has no effect on mice with hereditary diabetes (db/db) . Tetrathiomolybdate inhibit angiogenesis, also shows antiangiogenic effects in malignant pleural mesothelioma[1][2][3].
Product Specifications
CAS Number
16330-92-0
Product Name Alternative
TTM
UNSPSC
12352300
Target
Cuproptosis
Related Pathways
Apoptosis
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease; Cancer
Solubility
10 mM in DMSO
Smiles
S=[Mo-2](=S)(=S)=S
Molecular Formula
MoS4
Molecular Weight
224.22
References & Citations
[1]Zeng C, et al. Tetrathiomolybdate is partially protective against hyperglycemia in rodent models of diabetes. Exp Biol Med (Maywood) . 2008 Aug;233 (8) :1021-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Citation 01
Biomaterials. 2025 Jun 23:324:123523.|Cancer Cell. 2025 May 12;43 (5) :937-954.e9.|Cell Death Differ. 2024 Nov;31 (11) :1452-1466.|Cell Death Discov. 2025 Apr 25;11 (1) :197.|Clin Transl Med. 2025 Feb;15 (2) :e70221.|Eur J Med Res. 2025 May 19;30 (1) :394.|Free Radic Biol Med. 2024 Jun 10:S0891-5849 (24) 00521-5.|Neoplasia. 2025 Feb 3:61:101125.|Redox Biol. 2023 Dec:68:102952.|Tissue Cell. 2026 Feb:98:103221.|World J Gastroenterol. 2025 Sep 14;31 (34) :109825.|Acta Pharm Sin B. 2025 Apr;15 (4) :2095-2113.|Adv Healthc Mater. 2024 Jul 23:e2401954.|Adv Healthc Mater. 2025 Oct 2:e02769.|Biochem Biophys Res Commun. 2024 Jul 2:730:150341.|Biochem Pharmacol. 2025 Apr 10:116917.|Biomaterials. 2023 Jan:292:121945.|Cell Signal. 2025 Apr 28:132:111839.|Chem Eng J. 2025 Oct 9;524:169360.|Eur J Med Chem. 2025 Oct 8:301:118257.|Eur J Med Res. 2025 Jul 2;30 (1) :557.|Front Biosci (Landmark Ed) . 2025 Mar 6;30 (3) :36255.|Hum Cell. 2025 Jan 3;38 (2) :37.|iScience. 2024 Jul 14;27 (8) :110496.|J Ginseng Res. 2025 Oct 27.|J Inflamm Res. 2025 May 22:18:6607-6622.|Mol Med. 2025 Apr 4;31 (1) :126.|Part Fibre Toxicol. 2025 May 20;22 (1) :13.|Toxicol Appl Pharmacol. 2025 Oct:503:117496.
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