Sordarin

Sordarin (Compound 1) is an antifungal agent targeting Elongation factor 2 (EF2) with a tetracyclic diterpene core including a norbornene system. Sordarin can be isolated from the fungus Sordaria araneosa. Sordarin has potent antifungal activity against Saccharomyces cerevisiae and Candida albicans. Sordarin prevents the translocation of the ribosome along mRNA during elongation of the emerging polypeptide chain, inhibiting protein synthesis in fungi by stabilizing the ribosome/EF2 complex[1].

Product Specifications

CAS Number

[11076-17-8]

UNSPSC

12352005

Target

Fungal

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Smiles

OC([C@@]1([C@@]([C@@]2([H])[C@]([C@@H](CC2)C)([H])C3)(C4)C=O)[C@]3([C@@]4([H])C=C1C(C)C)CO[C@@H]5O[C@@H]([C@H]([C@H]([C@@H]5O)O)OC)C)=O

Molecular Formula

C27H40O8

Molecular Weight

492.60

References & Citations

[1]Liang H. Sordarin, an antifungal agent with a unique mode of action. Beilstein J Org Chem. 2008;4:31.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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