LRH-1 antagonist-1
LRH-1 antagonist-1 (Compound 3d2) is a LRH-1 antagonist with a Kd of 1.8 μM. LRH-1 antagonist-1 inhibits the transcriptional activity of LRH-1 and reduces the expression of G0S2. LRH-1 antagonist-1 inhibits the proliferation of LRH-1-positive cancer cells. LRH-1 antagonist-1 can be used for research on pancreatic cancer, colon cancer and breast cancer[1].
Product Specifications
CAS Number
[1185486-16-1]
UNSPSC
12352005
Target
Orphan Nuclear Receptor
Related Pathways
Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
CN(C)CCN(C=C1)N=C1C2=CC(C3=C(C)C(C)=NC(N(C)C)=N3)=CC=C2
Molecular Formula
C21H28N6
Molecular Weight
364.49
References & Citations
[1]Benod C, et al. Structure-based discovery of antagonists of nuclear receptor LRH-1. J Biol Chem. 2013 Jul 5;288 (27) :19830-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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