KRAS G12C-IN-72
KRAS G12C-IN-72 (Example 571) is a KRAS G12C inhibitor. KRAS G12C-IN-72 can be used as a target protein ligand to synthesize PROTACs, such as KRAS degrader-1 (HY-153880) . KRAS G12C-IN-72 can be used in cancer research[1].
Product Specifications
CAS Number
[2326523-41-3]
UNSPSC
12352005
Target
Ligands for Target Protein for PROTAC; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Field of Research
Cancer
Smiles
ClC1=CC=CC2=C1C(N3CC4=NC(OC[C@@H]5CCCN5)=NC(N6C[C@@H](N(CC6)C(C(F)=C)=O)CC#N)=C4CC3)=CC=C2
Molecular Formula
C31H33ClFN7O2
Molecular Weight
590.09
References & Citations
[1]James F. Blake, et al. Kras g12c inhibitors. US20190144444A1. United States. 2018-11-14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound
Clinical Information
No Development Reported
Isoform
K-Ras
Curated Selection
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