C20-Dihydrosphingomyelin

C20-Dihydrosphingomyelin (C20-DHSM; DHSM (d18:0/20:0) ) is a saturated form of Sphingomyelin (HY-113498) . C20-Dihydrosphingomyelin is a secondary component of most cell sphingolipids and its levels significantly decrease after intermittent fasting during Ramadan. C20-Dihydrosphingomyelin can be used for the development of liposome reagents[1][2][3].

Product Specifications

CAS Number

[917104-47-3]

Product Name Alternative

C20-DHSM; DHSM (d18:0/20:0)

UNSPSC

12352211

Target

Endogenous Metabolite; Liposome

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease

Smiles

CCCCCCCCCCCCCCCCCCCC(N[C@H]([C@H](O)CCCCCCCCCCCCCCC)COP(OCC[N+](C)(C)C)([O-])=O)=O

Molecular Formula

C43H89N2O6P

Molecular Weight

761.15

References & Citations

[1]Madkour MI, et al. Ramadan intermittent fasting is associated with ameliorated inflammatory markers and improved plasma sphingolipids/ceramides in subjects with obesity: lipidomics analysis. Sci Rep. 2023 Oct 13;13 (1) :17322.|[2]Kasagi N, et al. Optimization of dihydrosphingomyelin/cholesterol mol ratio in topotecan-loaded liposomes to enhance drug retention and plasma half-life by understanding physicochemical and thermodynamic properties of the lipid membrane. Journal of Molecular Structure. 2023 Jul 5;1283:135333.|[3]Yano M, et al. Quantitative analysis of ceramide molecular species by high performance liquid chromatography. J Lipid Res. 1998 Oct;39 (10) :2091-8. PMID: 9788256.