ZAK-IN-1

ZAK-IN-1 is an orally active and selective selective leucine-zipper and sterile‑α motif kinase (ZAK) inhibitor with IC50 of 4 nM and KD of 8 nM. ZAK-IN-1 exhibits excellent selectivity against a panel of 403 wild-type kinases. ZAK-IN-1 blocks p38/GATA-4 and JNK/c-Jun signaling and shows promising anti antihypertrophic cardiomyopathy (HCM) efficacy. ZAK-IN-1 can be used for the study of HCM[1].

Product Specifications

CAS Number

[2362525-64-0]

UNSPSC

12352005

Target

MAP3K

Related Pathways

MAPK/ERK Pathway

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Purity

98.43

Solubility

DMSO : 100 mg/mL (ultrasonic; warming)

Smiles

FC1=CC=C(NS(C2=CC=CC(C3=CC=CC=C3)=C2)(=O)=O)C(F)=C1N4N=NC(C5=CN=C(NN=C6OC)C6=C5)=C4

Molecular Formula

C27H19F2N7O3S

Molecular Weight

559.55

References & Citations

[1]Yang J, et al. Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors. J Med Chem. 2020 Mar 12;63 (5) :2114-2130.