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PFK-IN-1

PFK-IN-1 (compound 1) is a phosphofructokinase (PFK) inhibitor, with IC50 values of 0.41 and 0.23 μM against T.brucei and T.cruzi PFK, respectively, and an ED50 of 15.18 μg/mL for T.brucei. The half-lives of PFK-IN-1 in rat and mouse liver microsomes are 9.7 and 408 minutes, respectively[1].

Product Specifications

CAS Number

735303-62-5

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

Parasite

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Purity

98.12

Solubility

DMSO : ≥ 125 mg/mL

Smiles

O=C(NC1=CC=C(S(=O)(NC2=NOC(C)=C2)=O)C=C1)CC3=CC=C(Cl)C(Cl)=C3

Molecular Formula

C18H15Cl2N3O4S

Molecular Weight

440.30

Precautions

H302, H315, H319

References & Citations

[1]Kyle R Brimacombe, et al. Identification of ML251, a Potent Inhibitor of T. brucei and T. cruzi Phosphofructokinase. ACS Med Chem Lett. 2013 Oct 30;5 (1) :12-7.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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