MCC950 (sodium) (Standard)

MCC950 (sodium) (Standard) is the analytical standard of MCC950 (sodium) . This product is intended for research and analytical applications. MCC950 sodium (CP-456773 sodium; CRID3 sodium salt) is a potent, selective NLRP3 inhibitor with IC50s of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively.

Product Specifications

CAS Number

[256373-96-3]

UNSPSC

12352100

Target

NOD-like Receptor (NLR) ; Reference Standards

Related Pathways

Immunology/Inflammation; Others

Field of Research

Inflammation/Immunology

Smiles

O=S(C1=CC(C(C)(O)C)=CO1)([N-]C(NC2=C3CCCC3=CC4=C2CCC4)=O)=O.[Na+]

Molecular Formula

C20H23N2NaO5S

Molecular Weight

426.46

References & Citations

[1]Coll RC, et al. A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases. Nat Med. 2015 Mar;21 (3) :248-55.|[2]Zhai Y, et al. Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice. Molecules. 2018 Feb 27;23 (3) . pii: E522.