TH588 (Standard)
TH588 (Standard) is the analytical standard of TH588. This product is intended for research and analytical applications. TH588 is first-in-class nudix hydrolase family inhibitor that potently and selectively engage and inhibit the MTH1 (IC50= 5 nM) .
Product Specifications
CAS Number
1609960-31-7
UNSPSC
12352100
Target
DNA/RNA Synthesis; Reference Standards
Related Pathways
Cell Cycle/DNA Damage; Others
Field of Research
Cancer
Smiles
NC1=NC(C2=CC=CC(Cl)=C2Cl)=CC(NC3CC3)=N1
Molecular Formula
C13H12Cl2N4
Molecular Weight
295.17
References & Citations
[1]Gad H, et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool. Nature. 2014 Apr 10;508 (7495) :215-21.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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