ML171 (Standard)
ML171 (Standard) is the analytical standard of ML171. This product is intended for research and analytical applications. ML171 (2-Acetylphenothiazine;2-APT) is a potent and selective NADPH oxidase 1 (Nox1) inhibitor that blocks Nox1-dependent ROS generation, with an IC50 of 0.25 μM in HEK293-Nox1 confirmatory assay.
Product Specifications
CAS Number
[6631-94-3]
UNSPSC
12352100
Hazard Statement
H302, H412
Target
NADPH Oxidase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease
Purity
98.62
Smiles
CC(C1=CC=C2SC3=CC=CC=C3NC2=C1)=O
Molecular Formula
C14H11NOS
Molecular Weight
241.31
Precautions
H302, H412
References & Citations
[1]Gianni D, et al. A novel and specific NADPH oxidase-1 (Nox1) small-molecule inhibitor blocks the formation of functional invadopodia in human colon cancer cells. ACS Chem Biol. 2010 Oct 15;5 (10) :981-93.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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