ML121

ML121 is a selective and potent VIM-2 inhibitor with an IC50 of 54 nM and a Ki of 148 nM. ML121 shows inactive in IMP-1 and TEM-1 beta-lactamase assays. ML121 can potentiate the antibiotic activity of Imipenem (HY-B1369A) in VIM-2 transformed E.coli[1].

Product Specifications

CAS Number

[1212185-26-6]

UNSPSC

12352005

Target

Beta-lactamase

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C1SC(C(C2=CC=CN=C2)C3C(C4CCC3C4)S5)=C5N1

Molecular Formula

C16H16N2OS2

Molecular Weight

316.44

References & Citations

[1]Minond D, Set al. HTS Assay for Discovery of Novel Metallo-Beta-lactamase (MBL) Inhibitors. 2009 Nov 13. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD) : National Center for Biotechnology Information (US) .