DdATP (tetrasodium)

DdATP (2',3'-Dideoxyadenosine 5'-triphosphate) tetrasodium is an active metabolite of 2',3'-dideoxyadenosine and an inhibitor of chain elongation by DNA polymerase (DNA polymerase) . ddATP tetrasodium can be used in Sanger sequencing and research related to viral infections[1][2][3][4][5].

Product Specifications

Product Name Alternative

2',3'-Dideoxyadenosine 5'-triphosphate (tetrasodium)

UNSPSC

12352005

Target

DNA/RNA Synthesis; HIV

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Smiles

NC1=NC=NC2=C1N=CN2[C@H]3CC[C@H](O3)COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O

Molecular Formula

C10H12N5Na4O11P3

Molecular Weight

563.11

References & Citations

[1]van der Vliet PC, et al. Role of DNA polymerase gamma in adenovirus DNA replication. Mechanism of inhibition by 2',3'-dideoxynucleoside 5'-triphosphates. Biochemistry. 1981 Apr 28;20 (9) :2628-32. |[2]Xu Lan, et al. Simultaneous determination of 2 ,3 -dideoxyinosine and the active metabolite, 2 ,3 -dideoxyadenosine-5 -triphosphate in human peripheral-blood mononuclear cell by HPLC–MS/MS and the application to cell pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:337-42.|[3]Jun-Yu Ma, et al. Double-strand breaks induce short-scale DNA replication and damage amplification in the fully grown mouse oocytes. Genetics. 2021 Jun 24;218 (2) :iyab054.|[4]C M Perry, et al. Didanosine. An update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease. Drugs. 1996 Dec;52 (6) :928-62.|[5]Hao Z, et al. Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro. Mol Pharmacol. 1988 Oct;34 (4) :431-5.