ML114
ML114 is a specific inhibitor of RBBP9 serine hydrolase, with an IC50 of 0.63 μM against recombinant RBBP9. ML114 can inhibit the proliferation of human pluripotent stem cells (hPSCs) by regulating the expression of NFYA and other factors, but does not induce differentiation. ML114 can be used in the research of diseases such as retinoblastoma[1].
Product Specifications
CAS Number
866149-26-0
UNSPSC
12352005
Target
Phospholipase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Neurological Disease
Smiles
C/C(C1=NC=CS1)=N\OC(C2CCCCC2)=O
Molecular Formula
C12H16N2O2S
Molecular Weight
252.33
References & Citations
[1]Lim S, et al. Application of the RBBP9 Serine Hydrolase Inhibitor, ML114, Decouples Human Pluripotent Stem Cell Proliferation and Differentiation. Int J Mol Sci. 2020 Nov 26;21 (23) :8983.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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