ML114

ML114 is a specific inhibitor of RBBP9 serine hydrolase, with an IC50 of 0.63 μM against recombinant RBBP9. ML114 can inhibit the proliferation of human pluripotent stem cells (hPSCs) by regulating the expression of NFYA and other factors, but does not induce differentiation. ML114 can be used in the research of diseases such as retinoblastoma[1].

Product Specifications

CAS Number

[866149-26-0]

UNSPSC

12352005

Target

Phospholipase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Neurological Disease

Smiles

C/C(C1=NC=CS1)=N\OC(C2CCCCC2)=O

Molecular Formula

C12H16N2O2S

Molecular Weight

252.33

References & Citations

[1]Lim S, et al. Application of the RBBP9 Serine Hydrolase Inhibitor, ML114, Decouples Human Pluripotent Stem Cell Proliferation and Differentiation. Int J Mol Sci. 2020 Nov 26;21 (23) :8983.