Etrasimod-d9

Etrasimod-d9 (APD334-d9) is a deuterium labeled Etrasimod (HY-12789) . Etrasimod (APD334) is a potent, selective and orally available antagonist of the sphingosine-1-phosphate-1 (S1P1) receptor with an IC50 value of 1.88 nM in CHO cells.[1].

Product Specifications

Product Name Alternative

APD334-d9

UNSPSC

12352005

Target

Isotope-Labeled Compounds; LPL Receptor

Related Pathways

GPCR/G Protein; Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Smiles

FC(F)(F)C1=CC(COC2=CC=C(NC3=C4CC[C@@H]3CC(O)=O)C4=C2)=CC=C1C5([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C5([2H])[2H]

Molecular Formula

C26H17D9F3NO3

Molecular Weight

466.54

References & Citations

[1]Buzard DJ, et al. Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor. ACS Med Chem Lett. 2014 Nov 4;5 (12) :1313-7.