5-Hydroxy Propafenone (hydrochloride)

5-Hydroxy Propafenone (hydrochloride) is an inhibitor of cardiac myocyte repolarizing currents. 5-Hydroxy Propafenone is an active metabolite of propafenone. 5-Hydroxy Propafenone (hydrochloride) inhibits transient outward potassium current (Ito) in isolated human arterial myocytes with an IC50 of 1.5 μM. 5-Hydroxy Propafenone (hydrochloride) is potent Ito inhibitor in neonatal rat ventricular myocytes[1].

Product Specifications

CAS Number

[86383-32-6]

Product Name Alternative

GPV-129 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Biochemical Assay Reagents; Others; Potassium Channel

Related Pathways

Membrane Transporter/Ion Channel; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Smiles

[H]Cl.O=C(C1=CC(O)=CC=C1OCC(O)CNCCC)CCC2=CC=CC=C2

Molecular Formula

C21H28ClNO4

Molecular Weight

393.90

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Cahill, S. A., et al., (2001) . Transient outward current inhibition by propafenone and 5-hydroxypropafenone in cultured neonatal rat ventricular myocytes. Journal of cardiovascular pharmacology, 38 (3), 460–467.