Hydroxy Itraconazole-d6

Hydroxy Itraconazole-d6 (R-63373-d6) is deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

Product Specifications

Product Name Alternative

R-63373-d6

UNSPSC

12352005

Target

Fungal; Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Others

Smiles

O=C1N(C(C([2H])(C([2H])([2H])[2H])O)([2H])C)N=C([2H])N1C2=CC=C(N3CCN(CC3)C4=CC=C(C=C4)OCC5OC(C6=CC=C(C=C6Cl)Cl)(CN7N=CN=C7)OC5)C=C2

Molecular Formula

C35H32D6Cl2N8O5

Molecular Weight

727.67

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Mino Y, et al. Hydroxy-itraconazole pharmacokinetics is similar to that of itraconazole in immunocompromised patients receiving oral solution of itraconazole. Clin Chim Acta. 2013 Jan 16;415:128-32.