E6446 (dihydrochloride) (Standard)

E6446 (dihydrochloride) (Standard) is the analytical standard of E6446 (dihydrochloride) . This product is intended for research and analytical applications. E6446 dihydrochloride is a potent and orally acitve TLR7 and TLR9 antagonist, used in the research of deleterious inflammatory responses. E6446 dihydrochloride is also a potent SCD1 inhibitor (KD: 4.61 μM), significantly inhibiting adipogenic differentiation and hepatic lipogenesis through SCD1-ATF3 signaling. E6446 dihydrochloride also improves liver pathology in high-fat diet (HFD) -fed mice and may be useful in the study of non-alcoholic fatty liver disease (NAFLD) [1][2][3].