AM-6761
AM-6761 is a potent MDM2 inhibitor with an IC50 of 0.1 nM.
Product Specifications
CAS Number
1584732-36-4
UNSPSC
12352005
Target
E1/E2/E3 Enzyme; MDM-2/p53
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Solubility
10 mM in DMSO
Smiles
O=C(O)CC1=CN=C(C[C@]2(C)C(N([C@@H](C3CC3)CS(=O)(C(C)(C)C)=O)[C@H](C4=CC=C(Cl)C(F)=C4)[C@@H](C5=CC=CC(Cl)=C5)C2)=O)S1
Molecular Formula
C33H37Cl2FN2O5S2
Molecular Weight
695.69
References & Citations
[1]Gonzalez AZ, et al. Novel inhibitors of the MDM2-p53 interaction featuring hydrogen bond acceptors as carboxylic acid isosteres. J Med Chem. 2014 Apr 10;57 (7) :2963-88.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
136059 50 µg
EIF4B (Eukaryotic translation initiation factor 4B) discontinued
Sign In for Pricing
View Details 
bsm-62432R-PE-Cy5-TR 20 µL
ACSL4 Recombinant Antibody, PE-Cy5 Conjugated
Sign In for Pricing
View Details MBS5307947-01 7 mL
Mouse monoclonal Tn antigen antibody (Prediluted for IHC)
Sign In for Pricing
View Details MBS5307947-02 5x 7 mL
Mouse monoclonal Tn antigen antibody (Prediluted for IHC)
Sign In for Pricing
View Details